A new study found that having been prescribed an antidepressant previously was associated with an increased risk of depressive relapse after full recovery. The risk was about three times higher than for those who had never taken an antidepressant.

The research was led by Jay Amsterdam and Thomas Kim at the University of Pennsylvania and published in the Journal of Clinical Psychopharmacology.

They write, “These findings support prior evidence of a negative influence of the number of prior antidepressant treatment trials on the likelihood of response and suggest that the number of prior antidepressant trials may also be associated with a greater odds of depressive relapse and a shorter time to relapse.”

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